Ingredients

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Restore 3 has been scientifically formulated to relieve symptoms of fibro/IBS and other long term health conditions*. We recognize that the culprit of these autoimmune disorders have a common link: An overgrowth of pathogenic bacteria within the GI tract. That’s why Restore 3 is a thorough program utilizing 3 actions which help achieve lasting relief by providing the following action:

Disrupt – Disrupt Pathogenic Biofilm
Remove – Remove Bacterial Pathogens
Replenish – Replenish the Gut Microbiome

 

And Restore 3 accomplishes all of this all in one powerful supplement. Our formula relies on effective, all natural ingredients which are backed by numerous scientific studies. In addition to this, our state-of-the-art laboratory was specifically designed to manufacture and culture enzymes and probiotics.

All of which are made right here in the USA in a cGMP certified laboratory which holds a Drug Manufacturing License by the Food and Drug Branch, and is registered as a Drug Establishment with the FDA. Lastly, for over 20 years, our board of health care advisers – made up of MDs, naturopaths and scientists – have kept us up to date with the latest research in the health and supplement industry.

 

Serrapeptase-restore-3

Discovery #1: Proteolytic Enzymes – Protease S & Serrapeptase

Often referred to as the super enzyme, Serrapeptase and Protease S are the true workhorses of the biofilm disrupting component of this formulation. Biofilm is mostly made up of protein and sugars. In order to breakdown the tough wall of biofilm, it requires a lot of protein digesting enzymes and Protease & Serrapeptase are among some of the most powerful enzymes currently used [1]

Any biofilm disrupting supplement should have a minimum of 150,000 HUT (Hemoglobin unit on a Tyrosine basis) of activity. We made sure to provide a minimum of 200,000 HUT for our formula.

 

Magnesium-Malate-restore-3

Discovery #2: Magnesium Malate

Researchers have found that people with fibro/IBS have decreased levels of oxygen in their muscles, also known as muscle hypoxia [2]

Biopsies of those muscles have shown muscle tissue breakdown, mitochondrial damage, and low levels of ATP, which may help explain the widespread muscle pain characteristic of fibro/IBS. Magnesium malate has been shown to help ease muscle aches caused by tissue hypoxia because it helps the body to produce energy even under low oxygen or hypoxic conditions [3]

.

 

cellulase-restore-3

Discovery #3: Cellulase & Hemicellulase

No biofilm dissolving formula is complete without the use of cellulase and hemicellulase to support the break down of the polysaccharide element of biofilm. Polysaccharide are complex sugars that bind with protein molecules which actually make up most of the biofilm structure. If you don’t have these sugar dissolving compounds, you are missing a critical element to biofilm disruption.

 

amylase-enzyme-restore-3

Discovery #4: Glucoamylase & Amylase

Present in saliva, and also secreted by the pancreas, these enzymes serve 2 purposes in Restore 3: To support breakdown of the biofilm barrier by removing the free glucose molecules from biofilm walls, allowing their structures to further break down. And to convert these glucose molecules into immediate, usable energy for the body. Studies [4]

have shown glucoamylase may be useful in reducing gas, bloating, heartburn and loss of appetite.[5]

 

lipase-restore-3

Discovery #5: Lipase

Lipase is an enzyme the body uses to break down fats in food so they can be absorbed in the intestines. Lipase is produced in the pancreas, mouth, and stomach. Lipase isn’t a proteolytic (protein digesting), however it compliments the action that the proteolytic enzymes have by working on leftover fats and carbohydrates both in the intestinal tract and the bloodstream — cleaning up what proteolytics cannot touch.

 

probiotics fibromyalgia

Discovery #6: Bacillus Coagulans

Much research has been done on Bacillus coagulans in the past 10 years and several recent studies in particular have indicated B. coagulans to be a powerful catalyst in significantly improving abdominal pain and bloating in people with fibro/IBS and relieving symptoms of arthritis and other musculoskeletal conditions.[6]

,[7]

B. coagulans is one of the few probiotics that doesn’t require refrigeration and is able to survive the exposure to the acid and bile it encounters in the GI tract while having the unique ability to rapidly colonize once it reaches the intestinal tract. Most probiotic supplements do not go on to colonize the GI tract.

 

bacillus-subtilis-restore-3

Discovery #7: Bacillus Subtilis

Bacillus Subtilis has long been an important part of the traditional Japanese fermented food, Natto, and the consumption of this has been linked to several health benefits. B. subtilis also exists naturally in a healthy human G.I. tract. Just like B. coagulans, it is an extremely hearty, spore forming probiotic that requires no refrigeration and studies indicate its ability to target and colonize and crowd out [8]

pathogenic bacteria in the gut, produce protease and amylase enzymes and stimulate the growth of various lactobacillus species of beneficial probiotics. B. subtilis has also been used as an anti-bacterial and anti-fungal agent in industrial and medical applications [9]

and at one point was widely used as a broad spectrum antibiotic, which was lost after less costly methods of producing antibiotics were discovered[10]

.

 

 

restore 3 ingredients

 

The Native Formulas Difference

GMP_trust badgecGMP Manufacturing

We go over and beyond the current Good Manufacturing Practices (cGMP). All our processes are meticulous and detail orientated and geared to hinder mistakes. We have comprehensive SOPs, MBRs and MPRs. This ensures meticulous record keeping and quality assurance.

  1. SOP – Standard Operating Procedures
  2. MPR – Master Production Records
  3. BPR – Batch Production Records

Each task we do is documented in our SOPs. Each lot of each product we manufacture is made according to our BPRs. A simple BPR will require over 140 signatures and dates. Every step we take is documented.

Kosher star
Star-K is recognized globally as the most trusted kosher symbol. The Kosher Certification verifies that our facility is approved for the manufacture of products that meet strict Kosher requirements.

 

halal image
ISA is the oldest and most respected Halal Certifier in North America. The Halal Certification verifies that our facility is approved for the manufacture of products that meet strict Halal requirements.

 

 

Meticulous Quality Control: Laboratory Testing

Green-Check-Mark-3-21x19 Rigorous identity, potency and microbiological testing of all raw materials and finished goods lab woman testing microscope

Green-Check-Mark-3-21x19 Positive Controls – third party microbiological testing of medium to ensure no “false negative” results

Green-Check-Mark-3-21x19 On-site probiotic identification testing – Polymerase Chain Reaction (PCR) test validates correct species/strain

Green-Check-Mark-3-21x19 Full enzyme spectrum USP / FCC assays

Green-Check-Mark-3-21x19 HPLC analysis

Green-Check-Mark-3-21x19Bioavailability testing / Electrophoresis

Green-Check-Mark-3-21x19 USP enteric coating testing

Green-Check-Mark-3-21x19 FTIR identity testing of raw materials

Green-Check-Mark-3-21x19 Preservatives, Allergens, Western Blot testing capabilities

 

 

The Restore 3 Program
A Complete Enzyme & Probiotic Restoration Program

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Supporting References:

  1. Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics David Lebeaux, Jean-Marc Ghigo, and Christophe Beloin
[Fibromyalgic syndrome: new perspectives in rehabilitation and management. A review]

. [Article in Italian]

Melillo N, Corrado A, Quarta L, D’Onofrio F, Trotta A, Cantatore FP.

  • The relationship between serum antioxidant vitamins, magnesium levels, and clinical parameters in patients with primary fibromyalgia syndrome Sukran Tastan Sakarya, Yesim Akyol, Abdulkerim Bedir, and Ferhan Canturk
  • Mucosal Maltase-Glucoamylase Plays a Crucial Role in Starch Digestion and Prandial Glucose Homeostasis of Mice Buford L. Nichols, Roberto Quezada-Calvillo, Claudia C. Robayo-Torres, Zihua Ao, Bruce R. Hamaker, Nancy F. Butte, Juan Marini, Farook Jahoor, and Erwin E. Sterchi
  • Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review Heyll U, Münnich U, Senger V.
  • Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS.
    Hun
  • The Gastrointestinal Microbiome and Musculoskeletal Diseases: A Beneficial Role for Probiotics and Prebiotics Luis Vitetta,1,2,* Samantha Coulson,2 Anthony W. Linnane,1,3 and Henry Butt4
  • Pilot study: A randomised, double blind, placebo controlled trial of pancrealipase for the treatment of postprandial irritable bowel syndrome-diarrhoea Mary E Money, Jaroslaw Walkowiak, Chris Virgilio, Nicholas J Talley
  • Self-Organization in High-Density Bacterial Colonies: Efficient Crowd Control HoJung Cho, Henrik Jönsson, Kyle Campbell, Pontus Melke, Joshua W Williams,
  • The production of antifungal volatiles by Bacillus subtilis P.J. Fiddaman, S. Rossall
    Dr S. Rossall, University of Nottingham School of Agriculture, Sutton Bonington, Loughborough, Leics LE12 5RD, UK